Skip to main content
. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Acta Neuropathol. 2017 Feb 28;133(5):839–856. doi: 10.1007/s00401-017-1685-y

Fig. 2.

Fig. 2

Association plots from single variant analyses of CSF Aβ42. a Manhattan plot shows negative log10-transformed P values from the joint analysis of Aβ42. The horizontal lines represent the genome-wide significance threshold, P = 5 × 10−8(red) and suggestive threshold, P = 1 × 10−5(blue). Red arrows point to novel loci. The y-axis is truncated, the lowest P value on chromosome 19 was 4.78 × 10−94. b, c Regional association plots of novel loci are shown for SNPs associated with Aβ42 near GLIS1 (b) and within SERPINB1 (c). The SNPs labeled on each regional plot had the lowest P value at each locus and are represented by a purple diamond. Each dot represents a SNP and dot colors indicate LD with the labeled SNP. Blue vertical lines show recombination rate marked on the right-hand y-axis of each regional plot. Plots for previously reported loci are in Supplementary Fig. 7