Fig. 1.

Study design. Each person underwent a 3T (MRI-1) and a 7T MRI (MRI-2) scan obtained 2 weeks apart. In patients only, when a CEL was noted in postcontrast imaging of MRI-1, postcontrast sequences were obtained at the MRI-2 7T scan. The 7T scan, inclusive of pre-and postcontrast sequences, was also repeated a month later (MRI-3). On the same day of either MRI-1 or MRI-2, each patient underwent a clinical assessment to establish the EDSS score.

* Indicates the time when the clinical assessment was performed. See text for detailed explanation.