Table 3.
Standardized incidence ratios (SIR) and 95% confidence intervals (CI) for risk of second primary prostate cancer and absolute excess risk per 10,000 person-years among male breast cancer cases from the SEER 18 registries, 1988–2012
| SIR | (95% CI) | Excess risk per 10,000 | Mean person-years at risk | |
|---|---|---|---|---|
| Overall | 1.12 | (0.93–1.33) | 7.65 | 6.05 |
| Stratified estimates | ||||
| Age at index breast cancer, years | ||||
| 20–55 | 1.22 | (0.68–2.01) | 5.94 | 7.41 |
| 55–64 | 1.20 | (0.87–1.62) | 14.77 | 6.64 |
| 65–74 | 1.34 | (1.01–1.73) | 30.28 | 6.17 |
| 75+ | 0.54 | (0.29–0.93) | −34.17 | 4.28 |
| Race/ethnicity | ||||
| Non-Hispanic White | 1.12 | (0.91–1.37) | 8.33 | 6.23 |
| Black | 1.14 | (0.68–1.81) | 12.28 | 5.07 |
| Asian/Pacific Islander/Alaska Native | 1.16 | (0.38–2.70) | 5.88 | 6.35 |
| Hispanic | 1.01 | (0.33–2.35) | 0.32 | 5.31 |
| Breast cancer AJCC stage | ||||
| I | 1.36 | (1.04–1.75) | 23.70 | 7.25 |
| II | 1.17 | (0.87–1.54) | 11.18 | 6.04 |
| III | 0.71 | (0.36–1.28) | −19.29 | 4.83 |
| Hormone receptor status | ||||
| ER/PR negative | 0.26 | (0.01–1.44)a | −47.13 | 6.04 |
| ER and/or PR positive | 1.23 | (1.11–1.39) | 22.11 | 7.27 |
aEstimate based on <5 observed cases