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Kaplan-Meier survival curves demonstrating metastasis-free survival probability of high-risk breast cancer patients (n = 133). ER+ breast cancer patients with >3 lymph nodes affected were treated with anthracycline-based chemotherapy plus endocrine therapy. Patients were grouped according to their PITX2 DNA methylation score. PITX2 high gene methylation (quartile 4) predicts poor survival and PITX2 low gene methylation (quartiles 1–3) favorable survival (data reanalyzed from [44]).
