Fig. 2.

Flowchart of patient selection for TECTA analysis and the results. The selection of patients started with 1896 patients and patients with GJB2 and mitochondrial mutations, and unilateral, conductive, and syndromic hearing loss, and inner ear anomaly were excluded. Then, the 1215 patients were subjected to U-shaped audiogram selection and 21 patients had U-shaped audiogram. Next, the 1194 patients who did not meet the criterion for U-shaped audiogram were subjected to Shallow U-shaped audiogram selection and 46 patients had shallow U-shaped audiogram. For the 67 patients (21 patients with U-shaped and 46 patients with shallow U-shaped) were tested for TECTA mutation. Finally, 4 patients (none with U-shaped and 4 patients with shallow U-shaped) had pathogenic or possibly pathogenic variants