FIGURE 1.
Granulocyte colony-stimulating factor (G-CSF) in conjunction with vascular endothelial growth factor (VEGF) significantly increases the number of primordial follicles in transplanted ovaries by 160% over placebo (P = .003). Primordial follicle numbers in transplanted ovaries of mice injected with VEGF and G-CSF are not statistically significantly different from those of nontransplanted ovaries. Animals per group: n = 5–6. Mean number of follicles: VEGF only: 112 ± 45; vehicle: 182 ± 60; G-CSF/SCF (stem cell factor): 411 ± 93; G-CSF/VEGF: 534 ± 95.