Table 5.
Microscopic characterization of lymphocytic esophagitis in patients with non-achalasia primary motility abnormalities and dysmotiltiy-negative gastroesophageal reflux disease.
| Nutcracker esophagus, n=10, (%) |
Ineffective motility, n=7, (%) |
Diffuse spasm, n=5, (%) |
All PEMD, n=22, (%) |
DN-GERD, n=4, (%) |
P-value (all PEMD versus DN-GERD) |
|
|---|---|---|---|---|---|---|
| Lymphocytes, median (25th; 75th percentile) | 65 (58; 150) | 69 (75; 88) | 67 (73; 142) | 72 (63; 271) | 67 (61; 88) | |
| Distribution of increased IEL | ||||||
| Focal | 9 (90) | 6 (86) | 3 (60) | 18 (82) | 3 (75) | 1.0 |
| Diffuse | 1 (10) | 1 (12) | 2 (40) | 4 (18) | 1 (25) | 1.0 |
| Localization of increased IEL | ||||||
| Peripapillary | 9 (90) | 4 (57) | 3 (60) | 15 (68) | 2 (50) | .59 |
| Peripapillary/interpapillary | 1 (10) | 3 (43) | 2(40) | 6 (27) | 1 (25) | 1.00 |
| Diffuse | 0 | 0 | 0 | 1 (3) | 1 (25) | .29 |
| Prominent spongiosis | 3 (30) | 2 (29) | 2 (40) | 7 (32) | 0 | .55 |
| Cases with CD4-predominant IEL | 5 (50) | 6 (86) | 3 (60) | 14 (64) | 1 (25) | .28 |
| Cases with CD8-predominant IEL | 5 (50) | 1 (14) | 2 (40) | 8 (36) | 3(75) | .28 |
| CD4:CD8 ratio for CD4-predominant cases | 1.7 ± 0.3 | 3.4 ± 2.1 | 3.0 ± 1.8 | 2.7 ± 1.7 | 2.1 | - |
| CD4:CD8 ratio for CD8-predominant cases | 0.5 ± 0.2 | 0.1 | 0.3 ± 0.1 | 0.4 ± 02 | 0.1 ± 0.1 | .013 |
Abbreviations: IEL, intraepithelial lymphocytes; DN-GERD, dysmotility-negative gastroesophageal reflux disease; PEMD, non-achalasia primary motility disorders.