Table 1.
Changes in relative expression levels of selected marker genes following Snail1 expression in DLD-1 cells.
| Gene symbol | GenBank Accession | –Snail1→+Snail1 |
|---|---|---|
| CDH1 | NM_004360 | 0.001 |
| OCLN | NM_002538 | 0.078 |
| LAMA3 | NM_198129 | 0.067 |
| LAMB3 | NM_001017402 | 0.026 |
| LAMC2 | NM_005562 | 0.139 |
| COL4A2 | NM_001846 | 0.226 |
| ITGA1 | NM_181501 | 534 |
| COL1A2 | NM_000089 | 463 |
| ZEB1 | NM_001128128 | 69.1 |
| VIM | NM_003380 | 27.5 |
| LEF1 | NM_016269 | 3.83 |
| CTNNB1 | NM_001098210 | 4.20 |
| CDH2 | NM_001792 | 0.24 |
| CDH11 | NM_001797 | 0.99 |
| FN1 | NM_054034 | 1.18 |
| MMP-2 | NM_004530 | 3.39 |
| MMP-7 | NM_002423 | 0.98 |
| MMP-9 | NM_004994 | 1.07 |
Gene expression profiles of Snail1+ cells were compared using Agilent Whole Human Genome microarrays. Data are presented as the intensities of signals in Snail1+ cells relative to the corresponding signals from control DsRed+ cells.
CDH1, E-cadherin; OCLN, occludin; LAMA3, laminin alpha 3; LAMB3, laminin beta3; LAMC2, laminin gamma2; COL4A2, collagen type IV alpha 2; ITGA1, integrin, alpha 1; COL1A2, collagen, type I, alpha 2; VIM, vimentin; LEF1, lymphoid enhancer-binding factor 1; CTNNB1, catenin (cadherin-associated protein), beta 1; CDH2, N-cadherin; CDH11; cadherin-11; FN1, fibronectin; MMP-2, matrix metalloproteinase 2; MMP-7, matrix metalloproteinase 7; MMP-9, matrix metalloproteinase 9.