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. 2017 Sep 20;16:1536012117717852. doi: 10.1177/1536012117717852

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© The Author(s) 2017

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Figure 15. — Activation of a glucuronide prodrug conjugate by GUS. The active form of the drug is released through spontaneous decomposition of the self-immolative linker following enzyme-mediated hydrolysis.⁸⁴ GUS indicates β-glucuronidase.