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Molecular regulation of palatal shelf growth and patterning. (A) Sonic hedgehog (Shh) is a central node in the signaling networks regulating palatal shelf growth and patterning throughout the anterior-posterior axis. (B, C) Molecular pathways specific for regulating growth in the anterior and posterior regions of the palatal shelf, respectively. Arrows represent inductive relationships, and blunt arrows indicate inhibition. epi, epithelium; mes, mesenchyme.
