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. 2017 Jun 29;96(11):1257–1264. doi: 10.1177/0022034517716915

Figure 5.

Figure 5.

Inhibition of miR-17-92 family miRs results in aberrations in TGFB signaling in the maxilla of embryonic day 15.5 PMIS-miR-17-92 mice. (A) Levels of TGFBR1 are elevated in Plasmid-Based miRNA Inhibition System (PMIS) mice relative to wild type (WT). (B) Levels of TGFBR2 are elevated in PMIS mice relative to WT. (C) Levels of TGFB1 are reduced in PMIS mice relative to WT. (D) Levels of TGFB3 are reduced in PMIS mice relative to WT. (E) Levels of mature miR-17, miR-18, miR-19, and miR-92 family members are reduced in PMIS-miR-17-92 mice relative to WT. P > 0.05, n.s. *P < 0.05. **P < 0.01. ***P < 0.001. Values are presented as fold-change ± SE.