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. 2017 Jul 21;96(11):1306–1313. doi: 10.1177/0022034517719870

Figure 1.

Figure 1.

Eye closure defect in TgKRT14::Spry4 embryos at E17.5. Analysis and whole-mount imaging of wild-type (A), TgKRT14::Spry4 (B), and Irf6+/–;TgKRT14::Spry4 embryos (C) show an eye closure defect in embryos containing KRT14::Spry4 transgene but not wild-type littermates. Irf6 heterozygous embryos did not have an eye closure defect (data not shown). The eye closure defects were similar between TgKRT14::Spry4 and experimental embryos (B, C). A vascular defect was also observed in TgKRT14::Spry4 embryos (B). No other anatomic defects were detected on gross evaluation.