Table.
Craniofacial Phenotype of Arhgap29K326X Embryos at e13.5 and e14.5.
| Palatal Shelves Elevated | Palatal Shelves in Contact | Commissure Contacta | Palatal Shelf to Tongue Adhesion | Tooth Bud Adhesionb | Any Oral Adhesionc | Potentially Deleterious Adhesiond | ||
|---|---|---|---|---|---|---|---|---|
| Arhgap29+/+ | e13.5 | 0/3 0% |
0/3 0% |
2/3 67% |
0/3 0% |
0/3 0% |
0/3 0% |
0/3 0% |
| e14.5 | 7/7 100% |
5/7 71% |
3/7 43% |
0/7 0% |
0/7 0% |
0/7 0% |
0/7 0% |
|
| Arhgap29K326X/+ | e13.5 | 0/12 0% |
0/12 0% |
10/12 83% |
4/12 33% |
7/12 58% |
9/12*
75%* |
7/12 58% |
| e14.5 | 18/25 72% |
13/25 52% |
18/25 72% |
3/25 12% |
5/25 20% |
13/25*52%* | 5/25 20% |
a
The maxillary and mandibular oral epithelia in the lateral commissure (lateral to the tooth bud) are in contact.
b
Any instance of adhesion involving the maxilla or mandibular tooth bud with opposing epithelium.
c
Contact between a maxillary structure (including palatal shelves) and an opposing structure. This includes contact in the commissure only if it extends medially beyond the halfway point between the maxillary and mandibular tooth buds.
d
The adhesion involves a not-yet elevated palatal shelf and mandibular or lingual epithelium.
*
P < 0.05 when compared with wild type of the same time point, Fisher exact test.