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Mutations in NECTIN1 and CDH1 associated with cleft lip/palate (CL/P). Domain structures and sites of mutations found in patients with CL/P for NECTIN-1 (top, previously known as PVRL1) and E-cadherin/CDH1 (bottom). Mutation types are color-coded and indicated in the legend. CBD, catenin-binding domain; EC, extracellular cadherin domain; IgL, immuoglobulin-like loop; JMD, juxtamembrane domain; TM, transmembrane domain.
