T1 weighted MRI features suggestive of an underlying primary tauopathy include the humming bird sign resulting from atrophy of the dorsal midbrain and preserved pons (A, bottom image) suggestive of progressive supranuclear palsy, asymmetric parietal atrophy, right greater than left, suggestive of corticobasal degeneration (B, bottom image) and striking atrophy of the prefrontal cortex and anterior temporal lobe with secondary ventricular enlargement, worse of the left (C, bottom image) suggestive of Pick’s disease. Top images are normal MRI scans for comparison.