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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Hepatol. 2017 Jun 21;67(4):809–817. doi: 10.1016/j.jhep.2017.06.008

Figure 2.

Figure 2

Dietary interventions in C57BL/6J-Gli2+/− and C57BL/6J-WT littermates. Animals were exposed to (A) a high-fat (HF) diet for 12 weeks (females) or (B) a methionine-and choline-deficient (MCD) diet for 4 weeks (males). While there were no differences in body mass and body fat between strains fed the HF diet (see also Table S5), Gli2+/− mutants showed an increase in hepatic steatosis compared to WTs. Gli2+/− mice on the MCD diet also showed an increase in macrovesicular liver steatosis but in the presence of weight loss. Results are expressed as the mean ± SEM. **P<0.01. Student t test with Holm-Sidak correction for multiple comparisons was used for statistical analysis. Magnification: top panel, 400×; bottom panel, 100×. H&E, hematoxylin and eosin staining. ORO, Oil Red O staining.