Figure 1. Administration of old plasma into young ischemic rats worsensyoungyoungwrosew were outcomeafter ischemic stroke.

(A) Schematic illustrating intraperitonealinjection of young (2-month-old) or old (22-month-old) plasma into young ischemic rats 1 hr after onset of ischemia, twice per day for 3 days. (B) Infarct areas (white) in TTC-(red) stained coronal brain section from vehicle, young and old plasma-treated rats at 3 days after stroke. (C) Quantitative analysis of infarct volume in vehicle, young and old plasma-treated rats at 3 days after ischemic stroke. (D) Motor function deficits of young ischemic rats were assessed by beam balance test, EBST and sticky tape test on the 1^st and 3^rd day after administration with vehicle, young, or old rat plasma. Values presented as mean ± SEM. *P<0.05; **P<0.01, compared with vehicle-treated group. N=7-12 per group.