Supplementary Table 3.
Antihypertensive medication use in subgroups of the high CVD risk subjects
| High risk (n=1131) | ||||
|---|---|---|---|---|
| Estimated risk >20% | Diabetes | Established CVD | P value | |
| Total, n=1131 | ||||
| % (n) | 20.2 (229) | 63.66 (720) | 16.09 (182) | <0.01 |
| Definite hypertension, % (n) | 99.12 (227) | 80.97 (583) | 82.41 (150) | <0.01 |
| On BP medication, % (n) | 53.73 (123) | 61.52 (443) | 63.18 (115) | 0.073 |
| CCB, % (n) | 56.09 (69) | 54.40 (241) | 59.13 (68) | 0.654 |
| CCB with other meds % (n) | 44.9 (31) | 48.5 (117) | 50.0 (34) | |
| ARB, % (n) | 40.65 (50) | 48.08 (213) | 53.04 (61) | 0.150 |
| ARB with other meds % (n) | 48.0 (24) | 48.4 (103) | 52.5 (32) | |
| ACEI, % (n) | 5.69 (7) | 8.57 (38) | 4.34 (5) | 0.223 |
| BB, % (n) | 8.13 (10) | 10.83 (48) | 14.78 (17) | 0.256 |
| Diuretic, % (n) | 6.50 (8) | 2.70 (12) | 0.89 (1)^ | 0.032 |
| Chinese medicine, % (n) | 16.26 (20) | 10.83 (48) | 9.56 (11) | 0.190 |
| Chmed with other meds % (n) | 10.0 (2) | 27.1 (13) | 36.4 (4) | |
| 1 medication, % (n) | 14.60 (71) | 11.89 (76)^# | 3.19 (3)^^## | 0.652 |
| 2 medications, % (n) | 74.07 (360) | 68.23 (436) | 61.70 (58) | |
| ≥3 medications, % (n) | 22.01 (107) | 27.69 (177) | 31.91 (30) | |
| < 80 years, n=903 | ||||
| % (n) | 16.72 (151) | 67.77 (612) | 15.50 (140) | <0.01 |
| Definite hypertension, % (n) | 98.71 (77) | 83.33 (90) | 80.95 (34) | <0.01 |
| On BP medication, % (n) | 62.82 (49) | 59.25 (64) | 54.76 (23) | 0.687 |
| CCB, % (n) | 64.86 (48) | 55.67 (211) | 60.86 (56) | 0.276 |
| CCB with other meds % (n) | 41.7 (20) | 51.7 (109) | 51.8 (29) | |
| ARB, % (n) | 40.54 (30) | 49.34 (187)^^## | 53.26 (49)^^# | 0.247 |
| ARB with other meds % (n) | 50.0 (15) | 50.3 (94) | 55.1 (27) | |
| ACEI, % (n) | 5.40 (4) | 8.44 (32) | 3.26 (3) | 0.184 |
| BB, % (n) | 8.10 (6) | 10.81 (41) | 17.39 (16) | 0.127 |
| Diuretic, % (n) | 2.70 (2) | 2.90 (11) | 1.08 (1) | 0.612 |
| Chinese medicine, % (n) | 12.16 (9) | 11.34 (43) | 9.78 (9)^ | 0.877 |
| Chmed with other meds % (n) | 11.1 (1) | 27.9 (12) | 33.3 (3) | |
| 1 medication, % (n) | 70.27 (52) | 66.75(253) | 63.04 (58) | 0.570 |
| 2 medications, % (n) | 25.67 (19) | 28.49 (108) | 28.26 (26) | |
| ≥3 medications, % (n) | 4.05 (3) | 4.74 (18) | 8.69 (8) | |
| ≥ 80 years, n=228 | ||||
| % (n) | 34.21 (78) | 47.36 (108) | 18.42 (42) | <0.01 |
| Definite hypertension, % (n) | 98.71 (77) | 83.33 (90) | 80.95 (34) | <0.01 |
| On BP medication, % (n) | 62.82 (49) | 59.25 (64) | 54.76 (23) | 0.687 |
| CCB, % (n) | 42.85 (21) | 46.87 (30) | 52.17 (12) | 0.755 |
| CCB with other meds % (n) | 47.6 (10) | 26.7 (8) | 41.7 (5) | |
| ARB, % (n) | 40.81 (20) | 40.62 (26)^^## | 52.17(12)^^## | 0.598 |
| ARB with other meds % (n) | 45.0 (9) | 34.6 (9) | 41.7 (5) | |
| ACEI, % (n) | 6.12 (3) | 9.37 (6) | 8.69 (2) | 0.815 |
| BB, % (n) | 8.16 (4) | 10.93 (7) | 4.34 (1) | 0.620 |
| Diuretic, % (n) | 12.24 (6) | 1.56 (1) | 0 (0) | 0.018 |
| Chinese medicine, % (n) | 22.44 (11) | 7.81 (5) | 8.69 (2) | 0.059 |
| Chmed with other meds % (n) | 18.2 (2) | 20 (1) | 0 | |
| 1 medication, % (n) | 69.38 (34) | 82.81 (53) | 73.91 (17) | 0.384 |
| 2 medications, % (n) | 28.57 (14) | 17.18 (11) | 26.08 (6) | |
| ≥3 medications, % (n) | 2.04 (1) | 0 (0) | 0 (0) |
BP, blood pressure; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; BB, beta-blocker; CCB, calcium channel blocker.
p value is for ANOVA between 3 groups.
^
p<0.05,
^^
p<0.01, significantly different from estimated risk >20% group;
#
p<0.05,
##
p<0.01, significantly different from diabetes group;
On BP medication is for hypertensive individuals.
ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; BB, beta-blocker; BP, blood pressure; CCB, calcium channel blocker; Diuret, Diuretic; Chmed, Chinese medicine antihypertensive compound.