Table 5. mRNA expression of markers of cellular proliferation and regulators of cell cycle progression, marker of lamellar bodies in type II AECs, pulmonary surfactant lipid synthesis and transport in the lung of ABW and LBW lambs.
Gene name (MNE) | ABW (n = 9) | LBW (n = 7) |
---|---|---|
Proliferation and cell cycle progression | ||
PCNA | 0.015 ± 0.002 | 0.020 ± 0.006 |
KI-67 | 0.016 ± 0.001 | 0.024 ± 0.005 |
p27 | 0.027 ± 0.002 | 0.025 ± 0.002 |
CCND-1 | 0.017 ± 0.004 | 0.016 ± 0.002 |
Marker of lamellar bodies in type II AECs | ||
LAMP-3 | 0.088 ± 0.015 | 0.129 ± 0.024* |
Pulmonary surfactant lipid synthesis and transport | ||
PCYT1A | 0.041 ± 0.001 | 0.040 ±0.004 |
FAS | 0.035 ± 0.001 | 0.045 ±0.002* |
ABCA3 | 0.033 ± 0.002 | 0.037 ± 0.002 |
Data (mean ± SEM) were analysed using Student’s unpaired t-test. MNE, mean normalised expression; ABW, average birth weight; LBW, low birth weight
*P < 0.05.