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. 2017 Sep 26;12(9):e0181185. doi: 10.1371/journal.pone.0181185

Table 5. mRNA expression of markers of cellular proliferation and regulators of cell cycle progression, marker of lamellar bodies in type II AECs, pulmonary surfactant lipid synthesis and transport in the lung of ABW and LBW lambs.

Gene name (MNE) ABW (n = 9) LBW (n = 7)
Proliferation and cell cycle progression
PCNA 0.015 ± 0.002 0.020 ± 0.006
KI-67 0.016 ± 0.001 0.024 ± 0.005
p27 0.027 ± 0.002 0.025 ± 0.002
CCND-1 0.017 ± 0.004 0.016 ± 0.002
Marker of lamellar bodies in type II AECs
LAMP-3 0.088 ± 0.015 0.129 ± 0.024*
Pulmonary surfactant lipid synthesis and transport
PCYT1A 0.041 ± 0.001 0.040 ±0.004
FAS 0.035 ± 0.001 0.045 ±0.002*
ABCA3 0.033 ± 0.002 0.037 ± 0.002

Data (mean ± SEM) were analysed using Student’s unpaired t-test. MNE, mean normalised expression; ABW, average birth weight; LBW, low birth weight

*P < 0.05.