Fig. 5.

Fluxes of hydrocortisone (A), benzoic acid (B) and caffeine (C) through healthy and psoriatic skin substitutes. The samples were taken after 0, 1, 2, 4, 6, 8 and 24 h. Healthy substitutes with serum (HS+S), healthy substitutes cultured in serum-free condition (HS−S), psoriatic substitutes with serum (PS+S), and psoriatic substitutes cultured in serum-free condition (PS−S). The results were confirmed with cells from 3 (healthy substitutes) or 4 (psoriatic substitutes) patients (n=3 substitutes for each condition).