Table 1.
Cumulative amount of hydrocortisone, benzoic acid and caffeine through the healthy and psoriatic skin substitutes cultured with or without serum. All data presented are the mean±standard deviation. The results were confirmed with cells from 3 (healthy substitutes) or 4 (psoriatic substitutes) patients (n=3 substitutes for each condition).
| Condition |
Cumulative amount (×10-5µg) |
||
|---|---|---|---|
| 2 h | 4 h | 24 h | |
| Hydrocortisone | |||
| HS+S | 4.24±2.27 | 12.20±5.92 | 57.50±10.80 |
| HS-S | 12.90±6.10 | 33.60±18.10 | 227.00±97.80 |
| PS+S | 129.00±67.30** | 332.00±140.00** | 896.00±99.40** |
| PS-S | 476.00±118.00*** | 741.00±73.90*** | 920.00±29.50 |
| Benzoic acid | |||
| HS+S | 1.87±0.84 | 4.71±1.16 | 68.30±3.59 |
| HS-S | 9.61±4.59* | 24.70±11.60* | 377.00±172.00 |
| PS+S | 86.00±23.50** | 189.00±75.40** | 433.00±141.00** |
| PS-S | 213.00±60.50 | 360.00±58.60 | 521.00±31.60 |
| Caffeine | |||
| HS+S | 5.38±0.75 | 17.90±1.95 | 132.00±7.40 |
| HS-S | 16.20±5.22* | 48.50±6.86* | 115.00±28.80 |
| PS+S | 55.90±16.00** | 85.20±22.10** | 102.00±24.90 |
| PS-S | 83.20±25.60 | 115.00±11.20 | 124.00±2.99 |
*
significant between HS+S and HS-S),
**
significant between PS+S and HS+S), and
***
significant between PS+S and PS-S).