Fig. 1.

hUCB-MSCs prevent IL-23-induced psoriasis-like skin inflammation in mice. (a) Experimental scheme for the induction of IL-23-induced psoriasis-like skin inflammation and treatment with hUCB-MSCs in mice. (b) H&E staining of mouse ear skin. Bar=200 µm (c) Intradermal injection of IL-23 increased epidermal thickness, and treatment with hUCB-MSCs inhibited the IL-23-mediated increase in epidermal thickness. (d) Percentages of CD11b⁺, CD11c⁺, and CD4⁺ T cells in the skin were determined through flow cytometry. Psoriasis-related pro-inflammatory cytokine gene (e) and chemokine gene (f) expression was measured by real-time PCR. The results shown are representative of three independent experiments. A.U.: Arbitrary Unit. Data are shown as mean±SEM. *P<0.05, **P<0.005.