Table 2.
Disease and Survival Outcomes by Pre-Transplant Characteristics (Univariate)
OS |
PFS |
||||||
---|---|---|---|---|---|---|---|
Characteristic | N | Deaths | 2-year estimate (SE) | P-value | Events | 2-year estimate (SE) | P-value |
All Patients | 149 | 73 | 51% (5%) | 84 | 42% (5%) | ||
MRD Pre-Transplant | 0.22 | 0.08 | |||||
No | 117 | 53 | 55% (5%) | 60 | 47% (5%) | ||
Yes | 32 | 20 | 40% (10%) | OS | 24 | 28% (8%) | PFS |
MRD Pre-Transplant | 0.46 | 0.19 | |||||
No (0) | 117 | 53 | 55% (5%) | 60 | 47% (5%) | ||
Low (≤0.1) | 17 | 10 | 38% (13%) | 11 | 34% (12%) | ||
High (>0.1) | 15 | 10 | 44% (14%) | 13 | 21% (11%) | ||
Age | 0.02 | 0.05 | |||||
<40 years | 89 | 40 | 59% (6%) | 47 | 47% (6%) | ||
≥40 years | 60 | 33 | 38% (8%) | 37 | 33% (7%) | ||
Sex | 0.05 | 0.16 | |||||
Male | 91 | 50 | 45% (6%) | 54 | 37% (6%) | ||
Female | 58 | 23 | 61% (7%) | 30 | 49% (7%) | ||
Disease Status | 0.08 | 0.07 | |||||
1st CR/CRi | 72 | 29 | 63% (6%) | 36 | 51% (7%) | ||
Later CR/CRi | 77 | 44 | 41% (6%) | 48 | 34% (6%) | ||
Cytogenetic Risk | 0.98 | 0.71 | |||||
High | 80 | 39 | 55% (6%) | 47 | 44% (6%) | ||
Intermediate/Good | 54 | 26 | 48% (8%) | 29 | 39% (7%) | ||
Phenotype | 0.70 | 0.67 | |||||
T cell | 20 | 10 | 31% (13%) | 11 | 33% (12%) | ||
B cell | 129 | 63 | 54% (5%) | 73 | 44% (5%) | ||
Conditioning Regimen |
0.50 | 0.22 | |||||
TBI | 39 | 21 | 60% (8%) | 22 | 52% (8%) | ||
nonTBI | 110 | 52 | 47% (6%) | 62 | 37% (6%) | ||
Allotype | 0.21 | 0.57 | |||||
Matched Related | 84 | 38 | 53% (6%) | 47 | 43% (6%) | ||
Matched Unrelated | 65 | 35 | 49% (7%) | 37 | 42% (7%) | ||
Cell Type | 0.19 | 0.11 | |||||
PB (HPC-A) | 102 | 53 | 48% (5%) | 62 | 40% (5%) | ||
BM (HPC-M) | 47 | 20 | 59% (8%) | 22 | 48% (8%) |