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. 2017 Aug 25;6:e28046. doi: 10.7554/eLife.28046

Figure 7. Model.

Figure 7.

Shown is the regulatory circuit whereby Mmi1 recruits Mot2, likely in the context of Ccr4-Not, to ubiquitinate its own inhibitor Mei2. The E3 ubiquitin ligase Ubr1 is involved in the constitutive pathway of Mei2 turnover. Both Mot2 and Ubr1 contribute to maintain low levels of Mei2, thereby preserving the activity of Mmi1 and sustaining meiotic mRNAs suppression in vegetative cells.