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. 2017 Jan 9;9:232–237. doi: 10.1016/j.bbrep.2016.12.008

Fig. 5.

Fig. 5

Cinnamic acid (CA) shortens circadian period of wheel-running activity in mice. Mice were continuously housed in cages with running wheels for at least 20 days under constant darkness. DMSO vehicle or 0.1 mg/kg/day CA (0.11 μL/h) was then continuously infused via osmotic mini-pumps. Representative double-plot actograms of wheel running behavior of mice infused with vehicle (A) or CA (B, C). Circadian period of wheel-running activity in mice infused with vehicle or CA before (open bars) and during (filled bars) (D). *P<0.01 vs. before CA infusion (n=13); P<0.05 vs. vehicle infusion (n=15). All values are expressed as means±SEM.