Table 2. Conserved large stretches and blocks found among the MIPS homologous sequences.

Conserved Stretches	Domain	Converted sequences a	Blocks Involved
Stretch-1	NAD+—binding	45244464443448847747444448224473	Block-F (F.1 and F.2)
Stretch-2	NAD+—binding	34847588734546414444444	Block-E
Stretch-3	Catalytic	274441344444425774473824488144847	Block-D
		458732721472784411644787443454125	Block-C
		126444234534417224611377143644287	Block-B
		44287611744445444144444144724	Block-A

The three large conserved stretches found across 172 homologous sequences with similarity ≥30%, represent the two important domains of MIPS quaternary structure. The conserved blocks within eukaryotic sequences with similarity ≥70%, named as blocks A, B, C, D E and F are underlined.

^a The numbers from 1 to 8 in the converted sequences refer to the amino acids falling under Groups 1 to 8 as described in Materials and Methods, and Das et al. [20].