Fig. 4.

Phenotypic changes in macrophage-selective Usp2a transgenic (Tg) mice after being fed a high-fat diet (HFD) for one year. The Tg mice and their control C57BL/6 littermates were fed an HFD from the age of five weeks to one year. (A) Changes in body weight and food consumption. (B) Wet tissue weight of epididymal and mesenteric adipose tissues. (C) Plasma triglyceride, non-esterified fatty acids (NEFAs), and total cholesterol levels under normal feeding conditions in high-fat diet treatment. (D, E) Blood glucose (D) and insulin (E) were measured during both feeding and fasting conditions. (F) HOMA-IR. (G) Insulin tolerance test. Values presented are the mean±SD of four mice. *P<0.05 vs. control mice.