Fig. 5.

Effects of macrophage USP2 on the insulin sensitivity of glucose metabolism-competent organs. Macrophage-selective Usp2a Tg mice and control littermates were fed an HFD for six months. (A) Ratio of phosphorylated Akt (pAkt) to total Akt in mesenteric and epididymal adipose tissues, liver, and gastrocnemius muscle. (B) Ratio of phosphorylated insulin receptor β chain (pIRβ) to total IRβ in gastrocnemius muscle and liver. Values presented are the mean±SD of five mice. *P<0.05 vs. control mice.