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. 2017 Feb 28;10:62–69. doi: 10.1016/j.bbrep.2017.02.008

Fig. 4.

Fig. 4.

Tumor Imaging of Spherical Gold Nanoparticle Uptake. a ) The white light image of a tumor center showing the gold distribution (after a 21 μg intra-tumoral injection of pHLIP® and PEG coated spherical gold nanoparticles in PBS, pH7.4); b) the section from the tumor center stained with H&E; and c) the magnified image of the tumor section outlined by a square in panel b, which shows tumor (T) and muscle (M). The arrows on panels a and b indicate muscle tissue. d) The bright field image of tumor sections stained with silver enhancement solution and e) the fluorescent image of the same tumor section stained with DAPI to visualize cell nuclei; and f) an overlay of the bright filed and fluorescent images. The percentage of injected dose of gold accumulated within tumors of different masses is given in the text and in Supplementary Fig. S3.