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. Author manuscript; available in PMC: 2018 Feb 22.
Published in final edited form as: ACS Nano. 2017 Jul 19;11(8):8167–8177. doi: 10.1021/acsnano.7b03073

Figure 6.

Figure 6

Genetic characterization of cTBs in maternal blood samples collected from expectant mothers (#11–15, Table 2) with confirmed chromosomal aberrations in the fetuses. (a) cTB-derived aCGH data obtained from expectant mothers #11 and 12 showed trisomy 18 and trisomy 13, respectively. (b) The finding of fetal tetrasomy X in expectant mothers #13 by aCGH was confirmed by FISH on matching umbilical cord tissue. (c) The finding of fetal dual chromosomal aberrations (trisomy 18 and disomy Y) in aCGH was confirmed by FISH on matching umbilical cord tissue. (d) Detecting fetal chromosomal aberrations from the expectant mother #15: A red arrow indicates copy number loss from 9p24.3 to 9p22.2 (17.2 Mb), and a blue arrow indicates copy number gain from 14q32.13 to 14q32.33 (11.7 Mb), under the resolution of 1.8 Mb.