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Muted DDR in cohesive chordoma clusters as compared to well-spread 2D cells. Quantitation of the percentage of nuclei containing γH2AX foci in 2D cells (A) or 3D cells (B) following 8-Gy IR. Statistical significance assessed by two independent proportions test. **P < .005, as compared to no IR; *P < .005, comparing bracketed pair.
