Table 1.
Group comparison of subjects with ApoE4 (E4 group) and without ApoE4 (non-E4 group)
| E4 group | Non-E4 group | P value | |
|---|---|---|---|
| N (male/female) | 28 (10/18) | 89 (39/50) | NS |
| Age, mean ± SD | 71.6 ± 11.2 | 71.7 ± 12.2 | NS |
| MMSE, mean ± SD | 23.2 ± 6.6 | 24.6 ± 5.3 | NS |
| Diagnosis | NS | ||
| HC, N (%) | 4 (14.3) | 20 (22.5) | |
| MCI, N (%) | 11 (39.3) | 47 (52.8) | |
| Dementia, N (%) | 13 (46.4) | 22 (24.7) | |
| [18F]florbetapir PET | |||
| SUVR, mean ± SD | 1.18 ± 0.18 | 1.09 ± 0.17 | .03 |
| Beta-amyloid positivity, N (%) | 17 (60.7) | 28 (38.5) | .006 |
| Plasma (pmol/L), mean ± SD | |||
| Aβ1–40 | 57.76 ± 77.67 | 36.99 ± 20.41 | .02 |
| Aβ1–42 | 9.56 ± 19.8 | 4.54 ± 3.83 | .02 |
| Aβ1–42/Aβ1–40 | 0.14 ± 0.06 | 0.13 ± 0.08 | NS |
Abbreviations: Aβ, beta-amyloid; HC, healthy control; MCI, mild cognitive impairment; MMSE, Mini–Mental State Examination; NS, not significant; PET, positron emission tomography; SD, standard deviation; SUVR, standard uptake value ratio.