Table 2.
Multivariable analysis of NSAID administration and urine NGAL levels
| Time point | % increase in NGAL between groupsa | 95% Confidence Interval | P-valueb |
|---|---|---|---|
| 24 hours | −12 | (−31, 13) | 0.32 |
| 36 hours | 206 | (141, 288) | <0.001 |
| 48 hours | 367 | (267, 493) | <0.001 |
| 60 hours | 532 | (398, 703) | <0.001 |
| 72 hours | 561 | (420, 739) | <0.001 |
All variables in Table 1 were included as covariates in the multivariable analysis. Prior CPB was mildly significant (p=0.04) and was associated with a mean (95% confidence interval) increase in NGAL levels of 23% (1, 50). All other variables were not significant at the p<0.05 level.
represents the mean percentage increase in urine NGAL levels in those receiving NSAIDs compared to those who did not receive NSAIDs at each time point following CPB.
p-value for interaction term of NSAID administration with each corresponding time point.