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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Am J Obstet Gynecol. 2017 Jun 8;217(4):449.e1–449.e9. doi: 10.1016/j.ajog.2017.05.070
Outcome1 Definition
Surgical Site Infection (SSI:) Centers for Disease Control and Prevention National Healthcare Safety Network Definition: 22 Infection occurs within 30 days after operative procedure AND
 Superficial SSI Involves only skin and subcutaneous tissue of the incision; AND patient has at least one of the following:
  1. Purulent drainage from the superficial incision,

  2. Organisms isolated from an aseptically-obtained culture from the superficial incision or subcutaneous tissue,

  3. Superficial incision that is deliberately opened by a surgeon, attending physician, or other designee and is culture-positive or not cultured; and patient has at least one of the following signs or symptoms: pain or tenderness; localized swelling; erythema; or heat. A culture- negative finding does not meet this criterion,

  4. Diagnosis of a superficial incisional SSI by the surgeon or attending physician or other designee

 Deep Incisional SSI Involves deep soft tissues of the incision (eg, fascial and muscle layers; AND patient has at least one of the following:
  1. Purulent drainage from the deep incision,

  2. A deep incision that spontaneously dehisces, or is deliberately opened or aspirated by a surgeon, attending physician, or other designee and is culture-positive or not cultured; and patient has at least one of the following signs or symptoms: fever (>38 degrees C), localized pain, or tenderness. A culture negative finding does not meet this criterion,

  3. An abscess or other evidence of infection that is detected on gross anatomical or histopathologic exam, or imaging test

 Organ/Space SSI The infection appears to be related to the operation and the infection involves any part of the anatomy (organs or spaces), other than the incision, which was opened or manipulated during an operation and at least one of the following :
  1. Purulent drainage from a drain placed in the organ/space

  2. Organisms isolated from an aseptically obtained culture of the organ/space

  3. An abscess or any other evidence of infection involving the organ/space that is found on direct examination, during reoperation, or by histopathologic or radiologic examination

  4. Diagnosis of an organ/space SSI by a surgeon or attending physician

  5. Endometritis, defined as maternal temperature >38.0 ° C on two occasions over a four hour period, or any temperature > 39.0° C over a period of >12 hours after delivery with associated uterine tenderness, was considered organ/space SSI

Cellulitis Redness or induration around the cesarean incision, diagnosed and treated as cellulitis by the surgeon, attending physician, or outpatient physician
Seroma Collection of serous fluid at the cesarean incision, diagnosed and treated by the surgeon, attending physician, or outpatient physician
Hematoma Collection of bloody fluid at the cesarean incision, diagnosed and treated by the surgeon, attending physician, or outpatient physician
Wound Separation Any separation of the wound necessitating intervention, diagnosed by the surgeon, attending physician, or outpatient physician
1

All outcomes were validated by the principal investigator in the original trial who was blinded to study arm of participants.