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. Author manuscript; available in PMC: 2018 Sep 26.
Published in final edited form as: Mol Biosyst. 2017 Sep 26;13(10):2006–2014. doi: 10.1039/c7mb00276a

Figure 1.

Figure 1

Multidrug resistance (MDR) system. (a) Schematic of the AcrB-AcrA-TolC tripartite efflux system. Arrows indicate the substrate/proton antiport directions. (b) New cartoon representation of the crystal structure of AcrB trimers. Each monomer can be decomposed into trans-membrane domain, porter domain and docking domain. (c) Top view of the porter domains. Each monomer is composed of four subdomains: PC1, PC2, PN1 and PN2. (d) Ball and stick representation of the key residues in TM domain (region indicated by red box in (b)): Asp 407, Asp 408, Lys 940 and Thr978.