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Co-crystal structures of the FOXA2-DBD/DBE2 complex. (A) Overall structure of the FOXA2 forkhead domain bound to the DBE2 element in an asymmetric unit. FOXA2 molecules are shown in cyan, and DNA targets in orange. Sequence of the 16-bp DNA duplex (DBE2) used in the crystallization is listed below. (B) Structural representation of the FOXA2-DBD (chain C) bound to the DBE2 DNA (chains A and B). Secondary structure elements are labeled.
