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. Author manuscript; available in PMC: 2018 Jul 25.
Published in final edited form as: Biochemistry. 2017 Jul 11;56(29):3745–3753. doi: 10.1021/acs.biochem.7b00211

Figure 4.

Figure 4

Comparison with previous FOXA3-DBD/TTR structure (PDB ID 1VTN)23. (A) Overall structure comparison between FOXA2 (cyan) and previous FOXA3 (orange). (B) Bidentate hydrogen bonds between Asn and Ade were conserved in both structures. (C) A hydrogen bond formed between His209 and Thy8′ in the FOXA2-DBD/DBE2 structure but not in the FOXA3-DBD/TTR structure. (D) FOXA3 Arg210 formed hydrogen bonds with DNA in the FOXA3-DBD/TTR structure.