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. 2017 Sep 26;7:12302. doi: 10.1038/s41598-017-12435-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of astragaloside II (AS II) on cell proliferation and scratch wound closure in Caco-2 cells. (A) Chemical structure of AS II. (B) Caco-2 cells were treated with 0.01, 0.1, and 1 μM AS II for 24 hr. Cell proliferation was measured using a CCK-8 kit. (C) The Caco-2 cell monolayers were scratched and incubated with the indicated concentrations of AS II. Wound closure was photographed and quantified over time. Data represent mean ± SEM (n = 6). *p < 0.05, **p < 0.01, and ***p < 0.001 versus the untreated control.