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. 2017 Aug 23;47(5):663–669. doi: 10.4070/kcj.2017.0028

Figure 1.

Figure 1

Novel concept of a heart-gut axis. In patients with HF, microcirculatory disturbances result in gut epithelial dysfunction. HF is also associated with gut microbiota dysbiosis and possibly aberrant production of gut microbe-derived metabolites. The imbalance in microbe-derived metabolites together with gut epithelial dysfunction could contribute to cardiac dysfunction, inflammation, malnutrition, and other morbidities in HF patients.

HF = heart failure.