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. 2017 Sep 22;8:1173. doi: 10.3389/fimmu.2017.01173

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Copyright © 2017 Ge, Huang, Liu, Chen, Xie, Chen, Peng, Sun, Hou and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal analysis of miR-155 expression in peripheral blood mononuclear cells (PBMCs) of IA patients during telbivudine therapy. (A) miR-155 mRNA levels in PBMCs at baseline in the CR and NCR groups. (B) Receiver-operating characteristic (ROC) curve showed the suitability of miR-155 mRNA levels at baseline to predict a CR to telbivudine therapy. An area under the curve (AUC) of 1.0 occurs with an ideal test, whereas an AUC of <0.5 indicates a test of no diagnostic value. (C) Temporal dynamics of miR-155 mRNA levels in PBMCs of all patients. (D) Comparison of miR-155 mRNA levels among individuals in the CR group. (E) Comparison of miR-155 mRNA levels among individuals in the NCR group. IA, immune activation; CR, complete response; NCR, non-complete response.