Table 5.

PD parameters by H⁺/K⁺-ATPase genotype after single intravenous administration of dexlansoprazole 30 mg (Mean ± SD).

Parameter	Genotype	0–24 h	0–4 h	14–24 h
Median (pH)	WT (n = 8)	6.0 ± 1.1	5.6 ± 2.0	4.7 ± 1.7
	Het (n = 10)	6.0 ± 1.9	5.5 ± 2.5	4.9 ± 2.3
	Hom (n = 10)	7.5 ± 0.6	7.5 ± 0.6	6.7 ± 1.1
ΔMedian (pH)	WT (n = 8)	3.7 ± 1.0c	3.5 ± 1.7c	2.8 ± 1.7
	Het (n = 10)	4.0 ± 1.6	3.3 ± 2.0c	2.1 ± 1.9c
	Hom (n = 10)	5.5 ± 0.5a	5.8 ± 0.3a,b	4.7 ± 1.0b
Mean (pH)	WT (n = 8)	5.7 ± 0.9	5.1 ± 1.4	5.1 ± 1.3
	Het (n = 10)	5.9 ± 1.5	5.3 ± 2.0	5.1 ± 1.9
	Hom (n = 10)	7.0 ± 0.6	6.2 ± 0.8	6.6 ± 0.8
ΔMean (pH)	WT (n = 8)	3.0 ± 1.0c	2.9 ± 1.0c	2.6 ± 1.3
	Het (n = 10)	3.0 ± 1.0c	3.0 ± 1.2	1.9 ± 0.9c
	Hom (n = 10)	4.5 ± 0.7a,b	4.2 ± 0.3a	4.0 ± 1.1b
TpH≥3(%)	WT (n = 8)	81.1 ± 14.2	69.5 ± 24.9	70.7 ± 27.8
	Het (n = 10)	81.0 ± 20.9	70.6 ± 25.1	72.0 ± 33.7
	Hom (n = 10)	95.7 ± 1.3	78.0 ± 7.4	98.5 ± 1.8
ΔTpH≥3(%)	WT (n = 8)	52.6 ± 21.0c	54.0 ± 28.3	56.6 ± 27.3c
	Het (n = 10)	51.8 ± 14.2c	52.6 ± 22.2	44.1 ± 21.3c
	Hom (n = 10)	75.4 ± 7.6a,b	68.4 ± 8.6	84.0 ± 9.1a,b
TpH≥4(%)	WT (n = 8)	75.6 ± 17.1	63.3 ± 26.8	62.5 ± 31.5
	Het (n = 10)	74.9 ± 25.7	64.8 ± 28.6	63.2 ± 38.0
	Hom (n = 10)	91.7 ± 4.9	73.1 ± 12.6	91.0 ± 10.4
ΔTpH≥4 (%)	WT (n = 8)	57.3 ± 22.3	53.6 ± 23.3	50.7 ± 30.9c
	Het (n = 10)	54.9 ± 19.1c	51.0 ± 20.6	37.7 ± 20.5c
	Hom (n = 10)	79.9 ± 6.6b	67.5 ± 8.7	80.9 ± 11.2a,b
TpH≥6(%)	WT (n = 8)	57.1 ± 18.8	46.8 ± 27.3	43.7 ± 25.6
	Het (n = 10)	59.2 ± 25.9	50.5 ± 38.4	41.0 ± 26.2
	Hom (n = 10)	80.2 ± 7.5	70.3 ± 14.7	66.9 ± 17.6
ΔTpH≥6 (%)	WT (n = 8)	51.2 ± 17.1c	42.6 ± 23.6	33.3 ± 25.5c
	Het (n = 10)	47.2 ± 17.0c	46.0 ± 33.2	17.4 ± 11.2c
	Hom (n = 10)	75.3 ± 9.3a,b	67.9 ± 12.4	59.2 ± 21.4a,b
${\text{AUC}}_{\tau 1-\tau 2}^{\text{pH}-\text{t}}$ (pH·h)	WT (n = 8)	8, 329 ± 1, 266	1, 243 ± 339	3, 112 ± 804
	Het (n = 10)	8, 527 ± 2, 169	1, 296 ± 472	3, 069 ± 1, 139
	Hom (n = 10)	10, 171 ± 786	1, 517 ± 184	3, 955 ± 497
${\text{AUC}}_{\tau 1-\tau 2}^{\text{pH}-\text{t}}$ (pH·h)	WT (n = 8)	4, 354 ± 1, 385c	681 ± 248c	1, 572 ±776c
	Het (n = 10)	4, 311 ± 1, 380c	727 ± 297	1, 074 ± 478c
	Hom (n = 10)	6, 493 ± 1, 056a,b	1, 028 ± 84a	2, 405 ± 684a,b

^aP < 0.05 vs. WT;

^bP < 0.05 vs. hetrozygote;

^cP < 0.05 vs. homozygote.

PD, pharmacodynamic; WT, wildtype; het, heterozygote; hom, homozygote; T_pH≥3(%), percentage time of pH ≥ 3; T_pH≥4 (%), percentage time of pH ≥ 4; T_pH≥6 (%), percent time of pH ≥ 6; ${\mathrm{\text{AUC}}}_{\tau \mathit{\text{1}}-\tau \mathit{\text{2}}}^{\mathrm{\text{pH}}-\mathrm{\text{t}}}$, area under pH-time curve.