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. 2017 Sep 26;8:702. doi: 10.1038/s41467-017-00768-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Regulation of Foxp3 expression by Bcl11b. a Expression of Foxp3 in CD4⁺CD8⁻ mature thymocytes differentiated in Rag1-KO hosts from Bcl11b ^+/+ and Bcl11b ^m/m fetal liver progenitors. A representative histogram (left) along with a summary of five independent hosts (right) are shown. ***P < 0.001 (unpaired t-test). b Histogram showing Foxp3 induction from CD62L⁺CD4⁺ T cells after in vitro culture under Treg differentiation condition. One representative of two experiments. c Bcl11b ChIP-seq tracks at the Foxp3 gene in DP thymocytes. Gene structure, transcriptional orientation and position of conserved non-coding sequence (CNS) 3 are indicated. d Summary of ChIP-qPCR assay for binding of Wt (white bars) and hypomorphic (black bars) Bcl11b to CNS2 and CNS3 regions in the Foxp3 locus in neonatal total thymocytes. e ChIP-qPCR for binding of SATB1 to the CNS3 enhancer in the Foxp3 gene. Chromatin was collected from DP thymocyte precursors using mice with the indicated genotypes. Combined data from three independent ChIP experiments are shown. **P < 0.01 (unpaired t-test)