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. 2017 Sep 26;7:12317. doi: 10.1038/s41598-017-12017-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The IL-6 in situ hybridization of the clinical samples. A computed tomography (CT) image (A) and a picture of the surgical specimen (B) of a 52-year-old male patient with EGFR mutation-positive (Exon 19 deletion) lung adenocarcinoma (Case 4, lesion 5 in Table 1). (C,D) The in situ hybridization of IL-6 mRNA and HE and CAM5.2 staining of the cells in the tumor (C) and just around the tumor (D) in lung adenocarcinoma. IL-6 mRNA-positive lung cancer cells were detected in the clinical samples (red circle in C), and some normal lung epithelial cells located immediately around the tumor were also IL-6 mRNA-positive (arrow); however, the normal lung epithelial cells were mostly negative. (E) Double staining of IL-6 mRNA and CAM5.2 in the tumor cells and just around the tumor.