Table 2.
Experimental overview and dietary mineral oil exposures in male and female Dark Agouti rats, calculated from the MOSH-concentrations in the feed and feed consumption at week 2 and 10.
| Exposure | Route | n (females + males) |
Dietary mineral oil exposure mg/kg/b.w./day (median) (females + males) |
Duration (days) | |
|---|---|---|---|---|---|
| Week 2 | Week 10 | ||||
| 200 μl Pristane day 0 | i.d. | 5 + 5 | 0 + 0 | 0 + 0 | 40a |
| 4000 mg Pristane/kg feed | p.o. | 5 + 5 | 283.3 + 355.1 | 260.0 + 244.5 | 90 |
| 0 mg MOSH/kg feed | p.o. | 5 + 5 | 0 + 0 | 0 + 0 | 90 |
| 40 mg MOSH/kg feed | p.o. | 5 + 5 | 3.8 + 3.3 | 2.9 + 2.3 | 90 |
| 400 mg MOSH/kg feed | p.o. | 5 + 5 | 30.3 + 30.8 | 29.4 + 25.7 | 90 |
| 4000 mg MOSH/kg feed | p.o. | 5 + 5 | 317.6 + 309.3 | 280.1 + 238.8 | 90 |
i.d., intradermal; p.o., per oral.
a
Pristane-injected rats were included in the experiment for a maximum of 40 days. Rats with arthritic score >10 and/or weight reduction >10% per week were sacrificed for animal welfare reasons.