Fig. 2.

Examples of isoboles characterizing CuO-NP + PbO-NP combined subchronic toxicity: (a) for thrombocyte count (additivity); (b) for erythrocytes (synergism at low effect levels and additivity at high effect levels); (c) for diuresis subadditivity of unidirectional action at low effect levels and oppositely directed action at high effect levels. The doses of CuO and PbO are plotted on the axes in mg per rat. The numbers at the lines of the isoboles show the values of the effect Y (thrombocytes *109/L; erythrocytes *1012/L; diuresis in mL per 24 h).