Table 2.
Active systemic anaphylaxis in guinea pigs.
| Group |
Severity of anaphylaxis |
||||||
|---|---|---|---|---|---|---|---|
| Sensitizing antigen | Challenging antigen | No. of Animals | Asymptomatic (−) | Mild (±) | Moderate (+) | Severe (++) | Death (+++) |
| A. paniculata extract (25 mg/kg, p.o) | A. paniculata extract (12.5 mg/kg, p.o) | 5 | 4 | 1 | – | – | – |
| A. paniculata extract (25 mg/kg, p.o) | A. paniculata extract (2.5 mg/kg, i.v) | 5 | 1 | 4 | – | – | – |
| Andrographolide (8 mg/kg, p.o) | Andrographolide (4 mg/kg, p.o) | 5 | 2 | 3 | – | – | – |
| Andrographolide (8 mg/kg, p.o) | Andrographolide (0.8 mg/kg, i.v) | 5 | 0 | 5 | – | – | – |
| DMSO (10 ml/kg, p.o) | DMSO (10 ml/kg, p.o) | 5 | 1 | 4 | – | – | – |
| DMSO (10 ml/kg, p.o) | DMSO (1 ml/kg, i.v) | 5 | 0 | 5 | – | – | – |
| Ovalbumin + CFA (2.5 mg/kg, s.c) | Ovalbumin (1.67 mg/kg, i.v) | 5 | – | – | – | 3 | 2 |
Clinical signs of anaphylaxis scored 30 min following challenge administration.
DMSO: Dimethyl sulfoxide; CFA: Complete Freund's Adjuvant; p.o: per oral; s.c: sub-cutaneous; i.v: intravenous.