Table 2.
Comparison of Parkinson’s disease patients without and with EDS
| Variables | Without EDS (n = 288) | With EDS (n = 125) | p value |
|---|---|---|---|
| Age, years | 65.7 ± 8.9 | 64.1 ± 9.1 | 0.1167 |
| Men, n (%) | 147 (51.0) | 80 (64.0) | 0.0150 |
| HY stage* | 2.2 ± 0.7 | 2.3 ± 0.8 | 0.1935 |
| UPDRS II† | 7.6 ± 5.2 | 11.0 ± 6.6 | < 0.0001 |
| UPDRS III‡ | 18.9 ± 10.4 | 21.9 ± 11.2 | 0.0080 |
| Motor fluctuation, n (%) | 60 (20.8) | 48 (38.4) | 0.0002 |
| Dyskinesia, n (%) | 90 (31.3) | 53 (42.4) | 0.0287 |
| ESS | 5.5 ± 2.8 | 15.1 ± 3.7 | < 0.0001 |
| GDS-30§ | 11.1 ± 7.0 | 13.7 ± 7.8 | 0.0020 |
| Lateralityǁ, n (%) | 0.0024 | ||
| Right | 106 (37.1) | 47 (38.5) | |
| Left | 77 (26.9) | 50 (41.0) | |
| Symmetric | 103 (36.0) | 25 (20.5) | |
| Total LEDD | 829.2 ± 378.7 | 853.3 ± 390.7 | 0.4060 |
| Levodopa | 481.2 ± 254.6 | 504.0 ± 276.5 | 0.4150 |
| Ropinirole¶ | 8.2 ± 5.7 | 8.9 ± 4.9 | 0.2240 |
*
data missing from two patients (one patient without EDS, the other with EDS),
†
data missing from seven patients (six without EDS, the other with EDS),
‡
data missing from one in patients without EDS,
§
data missing from six patients (three without EDS, the other with EDS),
ǁ
data missing from five patients (two without EDS, the other with EDS),
¶
the mean value of ropinirole is presented as LEDD.
EDS: excessive daytime sleepiness, HY stage: Hoehn and Yahr stage, UPDRS: Unified Parkinson’s Disease Rating Scale, ESS: Epworth Sleepiness Scale, GDS-30: 30-item Geriatric Depression Scale, LEDD: levodopa equivalent daily dose.