Table 4.
Comparison of Parkinson’s disease patients without and with depression
| Variables | Without depression (n = 310) | With depression (n = 97) | p value |
|---|---|---|---|
| Age, years | 65.1 ± 9.0 | 65.6 ± 9.3 | 0.6280 |
| Men, n (%) | 180 (58.1) | 42 (43.3) | 0.0110 |
| HY stage* | 2.2 ± 0.7 | 2.4 ± 0.7 | 0.0170 |
| UPDRS II† | 7.6 ± 4.9 | 11.8 ± 7.1 | < 0.0001 |
| UPDRS III‡ | 19.1 ± 10.6 | 22.1 ± 11.2 | 0.0160 |
| Motor fluctuation, n (%) | 77 (24.8) | 29 (29.9) | 0.3220 |
| Dyskinesia, n (%) | 102 (32.9) | 39 (40.2) | 0.1870 |
| ESS | 7.7 ± 5.2 | 10.6 ± 5.6 | < 0.0001 |
| GDS-30 | 8.6 ± 4.7 | 22.4 ± 2.9 | < 0.0001 |
| Laterality§, n (%) | 0.4520 | ||
| Right | 119 (38.8) | 33 (34.7) | |
| Left | 96 (31.3) | 27 (28.4) | |
| Symmetric | 92 (30.0) | 35 (36.8) | |
| Total LEDD | 820.8 ± 392.1 | 847.7 ± 356.7 | 0.5460 |
| Levodopa | 482.6 ± 266.6 | 493.6 ± 246.2 | 0.7190 |
| Ropiniroleǁ | 8.4 ± 5.4 | 8.7 ± 6.0 | 0.5860 |
*
data missing from one patient with depression,
†
data missing from seven patients (one without depression, the other with depression),
‡
data missing from one in patients without depression,
§
data missing from five patients (three without depression, the other with depression),
ǁ
the mean value of ropinirole is presented as LEDD.
HY stage: Hoehn and Yahr stage, UPDRS: Unified Parkinson’s Disease Rating Scale, ESS: Epworth Sleepiness Scale, GDS-30: 30-item Geriatric Depression Scale, LEDD: levodopa equivalent daily dose.