Table 2.
Genotype and allele frequencies of VDR SNPs and associations with autism.
| Genotype/Allele | ASD n (%) | Control n (%) | OR (95% CI) Control vs. ASD | p-Value |
|---|---|---|---|---|
| Fok-I (rs2228570) FF | 38 (35) | 68 (35) | ||
| Ff | 51 (47) | 92 (47) | 0.99 (0.59–1.68) | 0.98 |
| ff | 19 (18) | 36 (18) | 0.94 (0.48–1.87) | 0.87 |
| F | 127 (58.8) | 228 (58.2) | 0.97 (0.7–1.4) | 0.88 |
| f | 89 (41.2) | 164 (41.8) | ||
| FF vs. Ff + ff | 0.97 (0.66–1.42) | 0.88 | ||
| Bsm-I (rs1544410) | ||||
| BB | 12 (11) | 24 (12) | ||
| Bb | 67 (62) | 118 (60) | 1.14 (0.53–2.42) | 0.74 |
| bb | 29 (27) | 54 (28) | 1.07 (0.47–2.46) | 0.86 |
| B | 91 (42.1) | 166 (42.3) | 1.01 (0.72–1.41) | 0.96 |
| b | 125 (57.9) | 226 (57.7) | ||
| BB vs. Bb + bb | 1.11 (0.65–1.9) | 0.71 | ||
| Taq-I (rs731236) TT | 33 (31) | 92 (47) | ||
| Tt | 61 (56) | 85 (43) | 2.00 (1.19–3.35) | 0.008 |
| tt | 14 (13) | 19 (10) | 2.05 (0.93–4.56) | 0.08 |
| T | 127 (58.8) | 269 (68.6) | 1.53 (1.08–2.16) | 0.02 |
| t | 89 (41.2) | 123 (31.4) | ||
| TT vs. Tt + TT | 2.08 (1.40–3.01) | 0.0004 | ||
| Apa-I (rs7975232) | ||||
| 22 (20) | 26 (13) | 3.32 (1.44–7.63) | 0.004 | |
| Aa | 73 (68) | 119 (61) | 2.41 (1.23–4.73) | 0.01 |
| aa | 13 (12) | 51 (26) | ||
| A | 117 (54.2) | 171 (43.6) | 1.53 (1.09–2.13) | 0.01 |
| a | 99 (45.8) | 221 (56.4) | ||
| aa vs. AA + Aa | 2.65 (1.6–4.3) | 0.0001 | ||
Genotype frequencies of VDR SNPs were determined in the control group and patients with autism, and also associations with autism. Odds ratios (ORs) with 95% confidence interval (CI) and p values were calculated for the wild/wild genotype versus the wild/mutant and mutant/mutant genotypes.