Table 3.
Genotype frequencies of VDR SNPs and associations with gender.
| ASD + non-ASD Control | OR (95% CI) Females vs. Males | p-Value | ||
|---|---|---|---|---|
| Female n (%) | Male n (%) | |||
| Fok-I (rs2228570) | ||||
| FF | 39 (34) | 67 (36) | FF vs. Ff + ff | 0.61 |
| Ff | 44 (47) | 88 (47) | 0.91 (0.62–1.32) | |
| Ff | 22 (19) | 33 (17) | ||
| Bsm-I (rs1544410) | ||||
| BB | 13 (11) | 23 (12) | BB vs. Bb + bb | |
| Bb | 67 (58) | 118 (63) | 0.9 (0.53–1.52) | 0.69 |
| Bb | 35 (30) | 48 (25) | ||
| Taq-I (rs731236) | ||||
| TT | 57 (50) | 68 (36) | TT vs. Tt +.tt | |
| Tt | 47 (41) | 99 (52) | 1.76 (1.2–2.6) | 0.0035 |
| Tt | 11 (9) | 22 (10) | ||
| Apa-I (rs7975232) | ||||
| AA | 11 (9) | 37 (20) | aa vs. AA + Aa | |
| Aa | 80 (70) | 112 (59) | 1.07 (1.07–1.65) | 0.75 |
| Aa | 24 (21) | 40 (21) | ||
Genotype frequencies of VDR SNPs were determined in the non-ASD control group and patients with autism, and also associations with gender. Odds ratios (ORs) with 95% confidence interval (CI) and p values were calculated for the wild/wild genotype versus the wild/mutant and mutant/mutant genotypes.